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Project ECHO® (Extension for Community Healthcare Outcomes) is a collaborative medical education model that aims to build workforce capacity in rural and underserved areas. Developed by clinicians at the University of New Mexico (UNM), the ECHO model is now being used to address health care shortages all over the world and across diseases and specialties—ranging from autism care for children to palliative care for older adults. With a particular focus on supporting groups with relatively limited evaluation resources, this resource describes evaluation methods that can be used to examine the implementation, outcomes, and value of Project ECHO clinics that aim to address a wide range of challenges related to health care access, delivery, treatment, and prevention, particularly in underserved communities.